RNA Framework is an all-in-one toolkit for the analysis of most NGS-based RNA structure probing and post-transcriptional modification mapping experiments.
It can handle most methods for querying RNA secondary structures, either based on RT drop-off (CIRS-seq, SHAPE-seq, Structure-seq, DMS-seq, PARS, etc.) or on mutational profiling (SHAPE-MaP, DMS-MaPseq, etc.),
and RNA post-transcriptional modification mapping approaches, either immunoprecipitation-based (m1A, m6A, m5C, hm5C, etc.) or single-base resolution (Ψ, 2'-OMe, etc.).
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